Transmembrane signalling
نویسندگان
چکیده
منابع مشابه
Calcium, phospholipid turnover and transmembrane signalling.
Turnover of phosphatidylinositol, which is provoked by various neurotransmitters, peptide hormones and many other biologically active substances, appears to serve as a signal for the transmembrane control of protein phosphorylation through activation of a novel protein kinase (C-kinase). The activation of this enzyme absolutely requires Ca2+ and phosphatidylserine. Diacylglycerol derived from t...
متن کاملCalcium, phospholipid turnover and transmembrane signalling
Turnover of phosphatidylinositol, which is provoked by various neurotransmitters, peptide hormones and many other biologically active substances, appears to serve as a signal for the transmembrane control of protein phosphorylation through activation of a novel protein kinase (C-kinase). The activation of this enzyme absolutely requires Ca2+ and phosphatidylserine. Diacylglycerol derived from t...
متن کاملTransmembrane signalling and the aspartate receptor.
BACKGROUND The aspartate receptor is a transmembrane protein that mediates bacterial chemotaxis. The structures of the periplasmic ligand-binding domain reveal a dimer, each subunit with four alpha-helix bundles, with aspartate binding to one of two sites at the subunit interface. The transmembrane regions of the receptor were not included in these structures. RESULTS To investigate the struc...
متن کاملSpatial organization of transmembrane receptor signalling.
The spatial organization of transmembrane receptors is a critical step in signal transduction and receptor trafficking in cells. Transmembrane receptors engage in lateral homotypic and heterotypic cis-interactions as well as intercellular trans-interactions that result in the formation of signalling foci for the initiation of different signalling networks. Several aspects of ligand-induced rece...
متن کاملThe structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.
Heterodimeric integrin adhesion receptors regulate cell migration, survival and differentiation in metazoa by communicating signals bi-directionally across the plasma membrane. Protein engineering and mutagenesis studies have suggested that the dissociation of a complex formed by the single-pass transmembrane (TM) segments of the alpha and beta subunits is central to these signalling events. He...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 1980
ISSN: 0022-2615,1473-5644
DOI: 10.1099/00222615-13-4-617